{"id":142,"date":"2026-04-24T14:24:01","date_gmt":"2026-04-24T14:24:01","guid":{"rendered":"https:\/\/www-2026.synopsis.uniroma2.it\/?page_id=142"},"modified":"2026-05-04T08:01:28","modified_gmt":"2026-05-04T08:01:28","slug":"work-packages","status":"publish","type":"page","link":"https:\/\/synopsis.uniroma2.it\/?page_id=142","title":{"rendered":"Work packages"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"142\" class=\"elementor elementor-142\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36be2cc e-flex e-con-boxed e-con e-parent\" data-id=\"36be2cc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t<h2 \n\t\tdata-interaction-id=\"6e3d7ac\" \n\t\tclass=\"e-heading-base\" \n\t\t \n\t\t\n\t>\n\t\n\t\t\tWork Packages\n\t\t<\/h2>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-85ee124 e-flex e-con-boxed e-con e-parent\" data-id=\"85ee124\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t\t<p class=\"e-8adb488-670cb7c e-paragraph-base\" data-interaction-id=\"8adb488\"  >\n\t\t\t\t\t\t\t\tThe project integrates microphysiological systems, advanced cytometry techniques, and data-driven analysis to evaluate drug efficacy in a physiologically relevant environment.\n\t\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a40518a e-flex e-con-boxed e-con e-parent\" data-id=\"a40518a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\n<hr class=\"e-b8da6b9-bfa1194 e-divider-base\" data-interaction-id=\"b8da6b9\"   \/>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-af661ee e-flex e-con-boxed e-con e-parent\" data-id=\"af661ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t<h3 \n\t\tdata-interaction-id=\"2dad32d\" \n\t\tclass=\"e-heading-base\" \n\t\t \n\t\t\n\t>\n\t\n\t\t\tWP1 \u2013 Organ-on-Chip Platform\n\t\t<\/h3>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ea57872 e-flex e-con-boxed e-con e-parent\" data-id=\"ea57872\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t\t<p class=\"e-2e16c97-3047d7c e-paragraph-base\" data-interaction-id=\"2e16c97\"  >\n\t\t\t\t\t\t\t\t<strong>Description<\/strong><br>This work package focuses on the development of a microphysiological system, MPS, reproducing the perivascular niche of bone tissue, a key site for cancer metastasis.<br><strong>Objectives<\/strong> <br>1. Reproduce the bone microenvironment in vitro <br>2. Mimic physiological fluid shear stress conditions <br>3. Enable controlled administration of therapeutic agents<br><strong>Main Activities<\/strong> <br>1. Design and fabrication of the organ-on-chip platform <br>2. Cell culture of bone and cancer cells <br>3. Experimental validation under dynamic conditions\n\t\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b7fb217 e-flex e-con-boxed e-con e-parent\" data-id=\"b7fb217\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\n<hr class=\"e-518af33-d686a04 e-divider-base\" data-interaction-id=\"518af33\"   \/>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-915eef3 e-flex e-con-boxed e-con e-parent\" data-id=\"915eef3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t<h3 \n\t\tdata-interaction-id=\"8d55dcb\" \n\t\tclass=\"e-8d55dcb-bc828b7 e-heading-base\" \n\t\t \n\t\t\n\t>\n\t\n\t\t\tWP2 \u2013 IODC Platform Development\n\t\t<\/h3>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fde11ab e-flex e-con-boxed e-con e-parent\" data-id=\"fde11ab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t\t<p class=\"e-02b413b-f9f264d e-paragraph-base\" data-interaction-id=\"02b413b\"  >\n\t\t\t\t\t\t\t\t<strong>Description<\/strong><br>This work package aims to develop an impedance optical-deformability cytometry (IODC) module for high-throughput characterization of cancer cells.<br><strong>Objectives<\/strong> <br>1. Probe electro-mechanical properties of cells 2. Enable high-throughput measurements <br>3. Integrate with the organ-on-chip system<br><strong>Main Activities<\/strong><br>1. Design and fabrication of the IODC device <br>2. System integration and calibration <br>3. Performance testing\n\t\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9ad5ba4 e-flex e-con-boxed e-con e-parent\" data-id=\"9ad5ba4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\n<hr class=\"e-e34e314-eb8a8e3 e-divider-base\" data-interaction-id=\"e34e314\"   \/>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7811dfb e-flex e-con-boxed e-con e-parent\" data-id=\"7811dfb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t<h3 \n\t\tdata-interaction-id=\"6ae0907\" \n\t\tclass=\"e-heading-base\" \n\t\t \n\t\t\n\t>\n\t\n\t\t\tWP3 \u2013 Data Acquisition\n\t\t<\/h3>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-84b0b05 e-flex e-con-boxed e-con e-parent\" data-id=\"84b0b05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t\t<p class=\"e-16151fa-995aa41 e-paragraph-base\" data-interaction-id=\"16151fa\"  >\n\t\t\t\t\t\t\t\t<strong>Description<\/strong><br>This work package is dedicated to collecting multimodal experimental data from the developed platforms.<br><strong>Objectives<\/strong> <br>1. Acquire high-quality time-lapse microscopy data <br>2. Collect IODC measurements <br>3. Ensure reproducibility of experiments<br><strong>Main Activities<\/strong> <br>1. Time-lapse microscopy (TLM) video acquisition <br>2. High-throughput IODC measurements \n\t\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a6c4dc e-flex e-con-boxed e-con e-parent\" data-id=\"0a6c4dc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\n<hr class=\"e-7a895b1-9069d49 e-divider-base\" data-interaction-id=\"7a895b1\"   \/>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8888d02 e-flex e-con-boxed e-con e-parent\" data-id=\"8888d02\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c2e3333 e-flex e-con-boxed e-con e-parent\" data-id=\"c2e3333\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\t\t<h3 \n\t\tdata-interaction-id=\"797c4c1\" \n\t\tclass=\"e-heading-base\" \n\t\t \n\t\t\n\t>\n\t\n\t\t\tWP4 \u2013 Data Analysis and Integration\n\t\t<\/h3>\n\t\t\t\t\t\t\t\t<p class=\"e-bc911cb-e619551 e-paragraph-base\" data-interaction-id=\"bc911cb\"  >\n\t\t\t\t\t\t\t\tThis work package focuses on advanced data processing and integration of multimodal signals to evaluate therapy efficacy.<br><strong>Objectives<\/strong> <br>1. Develop robust data analysis pipelines <br>2. Combine TLM and IODC signals <br>3. Achieve high prediction accuracy<br><strong>Main Activities<\/strong> <br>1. Signal processing and feature extraction <br>2. Multimodal data integration <br>3. Development of interpretable models \n\t\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8883bf2 e-flex e-con-boxed e-con e-parent\" data-id=\"8883bf2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a8cf813 e-flex e-con-boxed e-con e-parent\" data-id=\"a8cf813\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t\n<hr class=\"e-d08b34e-01c5467 e-divider-base\" data-interaction-id=\"d08b34e\"   \/>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a055aab e-flex e-con-boxed e-con e-parent\" data-id=\"a055aab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2e6a3d2 e-con-full e-flex e-con e-child\" data-id=\"2e6a3d2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t\t\t\t<p class=\"e-3a0095f-bd66ea1 e-paragraph-base\" data-interaction-id=\"3a0095f\"  >\n\t\t\t\t\t\t\t\t<em>This project has received funding from the European Union\u2019s Framework Programme for Research and Innovation Horizon Europe (2021-2027) under the Marie Sk\u0142odowska-Curie Grant Agreement No. 101202231<\/em>.\n\t\t\t\t\t<\/p>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70ac121 e-con-full e-flex e-con e-child\" data-id=\"70ac121\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t\t\t\n\t\t<img class=\"e-image-base e-25a2b48-4f4054b\" \n\t\t\t\t\tdata-interaction-id=\"25a2b48\" \n\t\t \n\t\t \n\t\t\t\t\t\t\t\t\tid=\"27\"\n\t\t\t\t\t\t\t\t\t\t\t\tsrc=\"https:\/\/synopsis.uniroma2.it\/wp-content\/uploads\/2026\/04\/EU-logo.png\"\n\t\t\t\t\t\t\t\t\t\t\t\twidth=\"304\"\n\t\t\t\t\t\t\t\t\t\t\t\theight=\"124\"\n\t\t\t\t\t\t\t\t\t\t\t\tsrcset=\"https:\/\/synopsis.uniroma2.it\/wp-content\/uploads\/2026\/04\/EU-logo.png 304w, https:\/\/synopsis.uniroma2.it\/wp-content\/uploads\/2026\/04\/EU-logo-300x122.png 300w\"\n\t\t\t\t\t\t\t\t\t\t\t\talt=\"\"\n\t\t\t\t\t\t\/>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Work Packages The project integrates microphysiological systems, advanced cytometry techniques, and data-driven analysis to evaluate drug efficacy in a physiologically 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