SYNergic multimodal platform for high-throughput anti-cancer bOne-metastases theraPy ScreenIngS
Overview
SYNOPSIS is a Marie Skłodowska-Curie Actions funded project aimed at developing an innovative organ-on-chip platform to study breast and prostate cancer metastases in bone tissue. The project integrates advanced microscopy and impedance optical-deformability cytometry (IODC) and artificial intelligence (AI) to investigate cancer cell behavior and therapy response.
Objectives
1. Organ-on-chip platform: design, fabrication, and testing of the microphysiological system, MPS, including the culturing of bone and cancer cells under fluid shear stress conditions and the administration of chemotherapeutic agents.
2. IODC: design, fabrication, and testing of the module.
3. Data acquisition: TLM videos of the cells in the MPS and IODC measurements.
4. Data Analysis: optimise processing strategies for TLM and IODC data to leverage the various signals available for evaluating therapy efficacy.
This project has received funding from the European Union’s Framework Programme for Research and Innovation Horizon Europe (2021-2027) under the Marie Skłodowska-Curie Grant Agreement No. 101202231.
